Royal Air Force Typhoon FGR4s have operated alongside France's air force in a combined operation on an subterranean weapons facility in Syria employed by the Daesh militant organization, as stated by the UK Ministry of Defence.
The site, identified by surveillance, was thought to be storing arms and explosives, the statement said, and was positioned in hills just to the north of Palmyra in the heart of Syria.
"The RAF jets utilized laser-guided Paveway IV weapons to strike a number of approach shafts providing entry to the site... initial indications indicate the objective was successfully hit," the MoD said.
There was no indication of any civilian casualties in the operation on Saturday evening and each participating jet made a safe return, the MoD added.
The Typhoon FGR4s were supported by a Voyager aerial refuelling aircraft.
IS - alternatively referred to as Daesh - enforced jihadist rule over parts of Syria and Iraq before its territorial defeat in 2019.
"This operation demonstrates the UK's leading role, and commitment to stand shoulder to shoulder with our partners, to eliminate any re-emergence of Daesh and their violent and radical beliefs in the area," the British Defence Secretary the minister said.
RAF aircraft have performed surveillance missions over Syrian airspace to "prevent any efforts to regroup" of Islamic State following its military defeat at the Baghuz confrontation in the year 2019, the ministry said.
"I must thank the personnel of the UK armed forces participating in this mission for their professionalism and their bravery," he said. "They were part of thousands of UK service members stationed over the holidays. This action, to remove militants who threaten our safety, demonstrates how our armed forces are prepared to act, all year round, ensuring Britain's security within its borders and strong abroad."
Last December, the American forces executed what it described as a "large-scale strike" on Daesh sites in the country, after an ambush resulted in the deaths of two US servicemembers and a civilian linguist in Palmyra.
The United Nations reports Islamic State still maintains between 5,000 and 7,000 combatants in both countries.
